Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Holders Spain were knocked out of Euro 2016 in a 2-0 defeat by Italy on Monday after goals by Giorgio Chiellini and Graziano Pelle set up a quarter-final with world champions Germany. Chiellini opened the scoring after 33 minutes while Pelle wrapped up the victory in stoppage time to end Spain's reign as European champions which covered the 2008 and 2012 tournaments.
Barcelona coach Ernesto Valverde will be banking on new signing Ousmane Dembele to fill the gap left by Neymar's departure as he looks to overcome off-pitch difficulties when the Catalans take on Espanyol on Saturday.
Treble-chasing Barcelona are exactly where they want to be as they prepare for two matches this week that could make or break coach Luis Enrique's first season in charge.
Last season's treble winners Barca are in their worst run of form in La Liga since coach Luis Enrique took charge in August 2014.
Coach Zinedine Zidane learned the lessons of predecessor Rafael Benitez's disastrous tactics in the last encounter and employed defensive midfielder Casemiro in favour of more attack-minded players, opting instead to sit and wait for Barcelona.
Lionel Messi scored twice as La Liga champions Barcelona saw off a persistent Valencia side, who had Eliaquim Mangala sent off in the first half, to win 4-2 on Sunday and stay on the heels of leaders Real Madrid.
De Rossi, who turned 36 on Wednesday, led Roma for the final time in a 2-1 victory over Parma at the Stadio Olimpico in May and finished his stint in the Italian capital with 616 appearances in 18 years.
Lionel Messi and Cristiano Ronaldo will go head-to-head once again for the title of world's best footballer after being short-listed along with Neymar on Monday for the 2015 FIFA Ballon d'Or.
Here are five talking points from the weekend in La Liga:
Real Madrid have enviously looked on as Barcelona claimed six La Liga titles in the last eight years, but Zinedine Zidane's side can take a huge step towards a first crown since 2012 with victory over their bitter rivals at the Nou Camp on Saturday.
Barcelona followed up Saturday's win over Real Madrid with another victory when Alexis Sanchez set the champions on their way to a 3-0 success at Celta Vigo on Tuesday that put them four points clear at the top of La Liga.
Cristiano Ronaldo and Lionel Messi will again be duelling for the title of world's best footballer after their names once again headed the shortlist on Thursday for The Best FIFA Men's Player.
The plane carrying Chapecoense to the Copa Sudamericana final, first leg against Atletico Nacional crashed into mountains outside Medellin, Colombia on November 28 after running out of fuel, killing 71 of the 77 people on board
Barca made a slow start to the campaign under their new coach but after beating Paris Saint Germain in the quarter-finals they are on course to repeat the treble success.
Barcelona's hopes of staging another sensational Champions League comeback fell flat against a hardened Juventus side who held the Catalans to a 0-0 draw at the Nou Camp on Wednesday to reach the semi-finals 3-0 on aggregate.
Barcelona are on the verge of Champions League elimination after being thrashed 3-0 by Juventus in Turin on Tuesday, and few believe lightning can strike twice.
Barcelona's amazing 6-1 victory over Paris St Germain on Wednesday that sent them through to the Champions League quarter-finals will forever stay in the memories of supporters, coach Luis Enrique said.
'I'm very happy and I can say that 2016 was the best year of my career, the trophy shows that people aren't blind and watch the games.'
Lionel Messi scored one penalty and missed another as his double helped Barcelona sweep Levante aside in the second half in a 4-1 victory on Sunday to maintain their perfect La Liga start.
Neymar scored twice as Barcelona reached the Champions League semi-finals.
News of all that's transpired on and off the football field
Suarez moved ahead of Ronaldo as the league's top scorer on 34 goals after netting four times, twice with penalties, in the space of 25 second-half minutes
World champions Spain held on for a 2-1 win over Haiti in a friendly on Saturday as they warmed up for this month's Confederations Cup.
Barcelona seized control of their King's Cup quarter-final tie against Atletico Madrid when Lionel Messi followed up his saved penalty to score and secure a 1-0 first-leg victory at the Nou Camp on Wednesday.
Paris St Germain made light of the absent Zlatan Ibrahimovic and a sub-standard start to the season to claim a 3-2 Champions League victory over Barcelona on Tuesday.
Barcelona dropped their first points of the La Liga season as their star-studded forward line misfired in a 0-0 draw away to Malaga on Wednesday.
New Chelsea signing Loic Remy grabbed the only goal as France squeezed past 2010 world champions Spain 1-0 in a friendly at the Stade de France.
Subdued atmosphere at the Nou Camp after the deadly attacks in the Catalan capital and the town of Cambrils.
Silva struck twice in the second half to further stretch the 2010 World Cup winners' lead after Barcelona's Jordi Alba had fired them into the lead in the sixth minute and Alvaro Morata had doubled their advantage midway through the first half.
Michael Jordan needed a Scottie Pippen, so did Lionel Messi with an Andres Iniesta by his side and Suresh Raina is that glue that admirably stuck around with Mahendra Singh Dhoni in highs, lows, and from Saturday, in retirement.
Barcelona eased into the King's Cup last 16 when goals from Pedro, Cristian Tello and Neymar secured a 3-0 second-leg victory at home to third-tier Cartagena on Tuesday for a 7-1 aggregate success.
Barcelona's Neymar struck twice to put the Spanish side in the Champions League final despite a 3-2 loss at Bayern Munich on Tuesday as they progressed 5-3 on aggregate and will face Real Madrid or Juventus next month.
Real Madrid's bid to land Gareth Bale from Tottenham Hotspur for a world record fee in the region of 100 million euros is out of place in the current economic climate, Barcelona coach Gerardo Martino said on Saturday.
Willian and Lionel Messi scored as Chelsea and Barcelona finished 1-1 after an absorbing first leg of their Champions League last 16 tie on Tuesday, while Bayern Munich, helped by two typical Thomas Mueller goals and two from Robert Lewandowski, romped to a 5-0 home win over Besiktas.
AS Roma pulled off one of the great Champions League comebacks by knocking Barcelona out with a remarkable 3-0 win in their quarter-final second leg on Tuesday, overcoming a 4-1 deficit from the first game to reach the last four on away goals.
News of all that's transpired on and off the football field
As Barcelona prepare to welcome back Pep Guardiola to the Nou Camp for Wednesday's Champions League game against Manchester City, check out how the club has evolved since the visionary coach departed in 2012.
Promoted Alaves dealt champions Barcelona a shock 2-1 defeat at the Nou Camp on Saturday while Cristiano Ronaldo returned from injury to help Real Madrid thrash Osasuna 5-2 and go two points clear at the top of La Liga. With Lionel Messi, Luis Suarez and Andres Iniesta on the bench, Barcelona went behind to the visitors in the 39th minute before Frenchman Jeremy Mathieu equalised in the 46th. Ibai Gomez then scored the winner in the 64th.
Factbox on Barcelona and Argentina forward Lionel Messi, who became his country's all-time top goalscorer on Tuesday when he scored his 55th international goal.